Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514253, 514307, 514318, 514339, 544124, 544364, 546147, 546193, A61K 3144, C07D40112

Patent

active

054552451

ABSTRACT:
This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.

REFERENCES:
patent: 3679692 (1972-07-01), Wu
patent: 3862953 (1975-01-01), Berger
patent: 4699907 (1987-10-01), Gasc
patent: 4880822 (1989-11-01), Effland
patent: 5006537 (1991-04-01), Effland
patent: 5021438 (1991-06-01), Junge
patent: 5039811 (1991-08-01), Effland
patent: 5102891 (1992-04-01), Effland
patent: 5177088 (1993-01-01), Effland
patent: 5214038 (1993-05-01), Effland
A. K. Sheinkman, et al. Chemical Abstracts 70, 19857b (1969).
T. K. Murray, et al., Psychopharmacology 105, 134 (1991) entitled "Reversal by Tetrahydroaminoacridine of Scopolamine-induced Memory and performance deficits in Rats", and published in the United States of America.
Nat'l Institute of Mental Health Publication #ADM90-1696 (1990) entitled "Useful Information on Alzheimer's Disease" & published in the USA.
James F. Flood, et al., Brain Research, 215, 177 (1981), entitled "Cholinergic Receptor Interactions and their Effects on Long-Term Memory Processing", and published in the Netherlands.
James F. Flood, et al., Psychopharmacology, 86, 61 (1985) entitled "Memory Enhancement: Supra-additive Effect of Subcutaneous Cholinergic Drug Combinations in Mice", and published in the USA.
Paul E. Gold, Behavioral and Neural Biology, 46, (1986), entitled "The Use of Avoidance Training in Studies of Modulation of Memory Storage" and published in the USA.
Paul E. Gold, Animal Learning & Behavior, 17, 94 (1989), entitled "Neurobiological Features Common to Memory Modulation by Many Treatments" and published in the USA.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1077505

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.