Plasmid for producing human insulin

Details Plasmid for producing human insulin Plasmid for producing human insulin

1984-06-27

1987-04-07

Terapane, John F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 68, 4351723, 435253, 435317, 435549, 530303, 530808, 935 13, 935 29, 935 47, 935 48, 935 51, 935 56, 935 73, 12N 120, C12P 2104, C12N 1500, C12P 2100

Patent

active

H00002453

ABSTRACT:
Recombinant plasmids are described that carry the structural gene for human proinsulin in expressible form. The human proinsulin structural gene is fused to a functional transport sequence. Host organisms transformed by the recombinant plasmids express a preproinsulin in vivo, and is transported across the host organism's cell wall. Following its recovery, in vitro methods are used to convert the human proinsulin to human insulin.

REFERENCES:
Chan et al., Proc. Natl. Acad. Sci. (US) 78 5401-5405 (1981).
Bell et al., Nature, vol. 282, 525-527 (1979).
Talmadge et al., Proc. Natl. Acad. Sci. (US) 77 3369-3373 (1980).

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