Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1993-07-29
1995-10-03
Kim, Kay K. A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
530404, 530405, 530408, 530409, 42419711, 4242441, A61K 39385, A61K 3909, C07K 1700
Patent
active
054550327
ABSTRACT:
This invention relates to compositions useful for inducing immunoprotection against infections by pathogenic organisms containing phosphocholine antigens, including Streptococcus pneumoniae and other microorganisms that have a phosphocholine antigen component of their membranes or capsids. This invention also relates to vaccines and methods for inducing immunoprotection against infection by these pathogenic organisms.
REFERENCES:
patent: 4451404, Van Rheenen
Laleral (1989) Clin. Exp. Immunol. 75:52-57.
Wallick et al. (1983) J. Immunol. 130(6):2871-2875.
Gupta et al. (1993) Vaccine 11(3):293-306.
Allison et al. in "Vaccines: New Approaches to Immunological Problems" ed. R. W. Ellis 1992 Butterworth-Heinemann, pp. 431-449.
Briles, David E. (1992) "Mouse Antibody to Phosphocholine Can Protect Mice from Infection with Mouse-Virulent Human Isolates of Streptococcus pneumoniae", Infection and Immunity, 60:1957-1962.
Brown, Mckay, et al. (1984) "Subpopulations of Antibodies to Phosphocholine in Human Serum", the Journal of Immunology, 132:1323-1328.
Bruderer, Urs, et al. (1989) "Antibody Combining Site Heterogeneity Within the Response to Phosphocholine Keyhole Limpet Hemocyanin", Molecular Immunology 26:63-71.
Kenny, James J., et al. (1991) "Receptor-Mediated Elimination of Phosphocholine-Specific B Cells in X-linked Immune-Deficient Mice", The Journal of Immunology, 146:2568-2577.
Mond, James J., et al. (1977) "Inability of Mice With a Defect in B-Lymphocyte Maturation to Respond to Phosphorylcholine on Immunogenic Carriers", The Journal of Experimental Medicine, 146:1138-1142.
Spande, Thomas F. (1980) "Synthesis of Two Novel Phosphorycholine Esters for Probes in Immunological Studies" Journal of Organic Chemistry, 45:3081-3084.
Wallick, Susan, et al. (1983) "Resistance to Streptoccous pneumoniae is Induced by a Phosphocholine-Protein Conjugate", The Journal of Immunology, 130:2871-2875.
Wicker, Linda S. (1982) "Antibodies from the Lyb-5.sup.- B Cell Subset Predominate in the Secondary lgG Response to Phosphocholine", the Journal of Immunology, 129:950-953.
Wicker, Linda S., et al. (1983) "The Asymmetry in Idiotype-Isotype Expression in the Response to Phosphocholine is Due to Divergence in the Expressed Repertoires of Lyb-5.sup.+ and Lyb-G.sup.- Cells", the Journal of Immunology, 131:2468-2476.
Yother, Janet, et al. (1982) "Protection of Mice from Infection with Streptococcus pneumoniae by Anti-Phosphocholine Antibody", Infection and Immunity, 36:184-188.
Kenny James J.
Long Dan L.
Kim Kay K. A.
The United States of America as represented by the Department of
LandOfFree
Use of phosphocholine hapten conjugates in vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of phosphocholine hapten conjugates in vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of phosphocholine hapten conjugates in vaccines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1076056