Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1995-06-16
1997-08-05
Acquah, Samuel A.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
528361, 528363, 525425, 525437, 435180, 424418, C08F28300, C08G 6306
Patent
active
056543816
ABSTRACT:
Synthetic, functionalized, graft copolymers of polyesters and amino acids are provided. The copolymers are formed in one embodiment by providing a linear polyester-poly(amino acid) copolymer, and reacting the amino acid groups in the linear polymer with an amino acid derivative in a polymerization reaction to form a comb-like, graft copolymer including a polyester-amino acid backbone and polyamino acid side chains extending from the amino acid groups in the backbone. The poly(amino acid) includes functional groups which permit the covalent or ionic attachment of a biological molecule to the graft copolymer. The functionalized graft copolymers can be used in a wide range of biomedical applications including tissue engineering and drug delivery.
REFERENCES:
patent: 5399665 (1995-03-01), Barrera et al.
Freed, et al., "Biodegradable Polymer Scaffolds For Tissue Engineering", Bio/Technology, 12:689-693 (1994).
Gilding and Reed, "Biodegradable Polymers For Use In Surgery-Polyglycolic/Poly(Actic Acid) Homo-And Copolymers:1", Polymer, 20:1459-1464 (1979).
Goodman and Gilon, "Polydepsipeptides 1, Synthesis And Characterization Of Copolymers Of .alpha.-Amino And .alpha.-Hydroxy Acids", Israel Journal Of Chem., 10:867-879 (1972).
Hrkach, et al., "Poly(I-lactic Acid-Co-Amino Acid) Graft Copolymers: A Class Of Functional, Biodegradable Biomaterials", Macromolecules, Chapter XX, submitted (Jun. 1995).
Imanishi, Ring-Opening Polymerization, Ivin, K.J. and Saegusa, T., Eds., Elsevier, London, 1984, vol. 2, Chapter 8.
Kricheldorf, Models Of Biopolymers By Ring-Opening Ploymerization, Penczek, S., Ed., CRC Press, Boca Raton, Chapter 1 (1990).
Kricheldorf, .alpha.-Aminoacid-N-Carboxy-Anhydrides And Related Heterocycles, Springer-Verlag, Berlin, 1987.
Langer and Vacanti, "Tissue Engineering", Science, 260:920-926 (1993).
Li, et al., "Structure-Property Relationship In The Case Of The Degradation Of Massive Poly(.alpha.-Hyroxy Acids) In Aqueous Media", J. Mater. Sci. Mater. Med., 1:131-139 (1990).
Massia, S.P. and Hubbell, "An RGD Spacing Of 440 nm Is Sufficient For Integrin .alpha.v.beta.3-Mediated Fibroblast Spreading And 140 nm for Focal Contact And Stress Fiber Formation", J.A., J. Cell. Biol., 114:10891100 (1991).
Mooney, et al., "Design And Fabrication Of Biodegradable Polymer Devices To Engineer Tubular Tissues", Cell Transpl., 2:203-210 (1994).
Sela, et al., "Multichain Polyamino Acids", J. Am. Chem. Soc., 78:746-751 (1956).
Barrera, et al., "Synthesis And RGD Peptide Modification Of A New Biodegradable Copolymer: Poly(lactic acid-co-lysine)", J. Am. Chem. Soc., 115:11010-11011 (1993).
Barrera, et al., "Copolymerization And Degradation Of Poly(lactic acid-co lysine)", Macromolecules, 28:425-432 (1995).
Daly, et al., "The Preparation Of N-Carboxyanhydrides Of .alpha.-Amino Acids Using Bis(Trichloromethyl)Carbonate", Tetrahedron Lett., 29:5859-5862 (1988).
Hrkach Jeffrey S.
Langer Robert S.
Lotan Noah
Acquah Samuel A.
Massachusetts Institute of Technology
LandOfFree
Functionalized polyester graft copolymers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functionalized polyester graft copolymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functionalized polyester graft copolymers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1075577