Preparation of optically active .beta.-hydroxyester derivatives

Details Preparation of optically active .beta.-hydroxyester derivatives Preparation of optically active .beta.-hydroxyester derivatives

1999-09-17

2000-09-19

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 708, C07F 718

Patent

active

061214752

ABSTRACT:
In a process for preparing an optically active .beta.-hydroxyester derivative by enantioselective aldol addition reaction between an aldehyde and a ketene silylacetal, the enantioselective aldol addition reaction is performed in the presence of an organic base and a platinum-containing catalyst composed of an optically active bisphosphine-platinum complex having two P--Pt bondings which are equivalent to each other, showing in its .sup.31 P NMR spectrum a single peak assigned to P--Pt bonding.

REFERENCES:
patent: 5354879 (1994-10-01), Konoike et al.
patent: 5985853 (1999-11-01), Laugraud et al.

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