MDR1 retroviral plasmid

Details MDR1 retroviral plasmid MDR1 retroviral plasmid

1993-02-25

1997-08-05

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 435357, C12N 510, C12N 1586

Patent

active

056541872

ABSTRACT:
Existing plasmids, such as pHaMDR/A (available from NIH) are large and cumbersome. The size may limit the known utility of MDR1 as an effective selectable marker in gene transfer experiments. The invention provides novel plasmids including heterologous promoters and cDNA sequences positioned between the retroviral LTRs.

REFERENCES:
Miller et al., "Improved Retroviral Vectors for Gene Transfer and Expression", BioTechniques, vol. 7, No. 9 (1989) pp. 980-990.
Germann et al. "Retroviral Transfer of a Chimeric Multidrug Resistance-Adenosine Deaminase Gene", FASEB Journal, vol. 4, Mar. 1990, pp. 1501-1507.
Kane et al., "A New Vector Using the Human Multidrug Resistance Gene as a Selectable Marker Enables Overexpression of Foreign Genes in Eukaryotic Cells" Gene, vol. 84, 1989, pp. 439-446.

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