Polypeptide, process for preparing the same and pharmaceutical c

Details Polypeptide, process for preparing the same and pharmaceutical c Polypeptide, process for preparing the same and pharmaceutical c

1994-12-05

1997-08-05

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 514 12, 514844, 514969, 530350, 536 237, A61K 700, A61K 3816, C07K 1431, C12N 1531

Patent

active

056541716

ABSTRACT:
The present invention relates to a polypeptide (CIF Cornifation Inhibiting factor) characterized in that the polypeptide has a sequence of 212 amino acid residues represented by the formula (1) and a molecular weight of about 24000 daltons as determined by SDS-PAGE, a process for preparing the polypeptide, pharmaceutical compositions and cosmetics comprising the polypeptide, and a method of preventing or curing symptoms of skin diseases due to abnormal cornification of the skin with use of the polypeptide.

REFERENCES:
Sugai, M. et al. Cell.Struct.Funct. 12(4):395-400 (1987).
Sugai, M. Hiroshima Daigaku Shigaku Zasshi 19(2):391-401.
Inoue, S. Biochem. Biophys. Res. Comm. 174:459-464. (1991).
Lee, C.C. et al. Science 239:1288-1291 (1988).

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