Multicolor in situ hybridization methods for genetic testing

Details Multicolor in situ hybridization methods for genetic testing Multicolor in situ hybridization methods for genetic testing

1995-05-23

1997-08-05

Campbell, Eggerton A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, C12Q 168, C12Q 170

Patent

active

056541481

ABSTRACT:
This invention relates to novel methods of optimally analyzing commonly obtained prenatal cell samples by in situ hybridization. In addition, this method diagnoses gene deletion and gene multiplication using multicolor in situ hybridization. A method is also provided to use multicolor in situ hybridization to identify chromosomal haplotypes co-segregating with disease-related genetic alterations and with normal genes. This haplotype in situ protocol simplifies haplotype segregation analysis in pedigrees.

REFERENCES:
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Grito et al, Archives of Pathol. & Lab. Medicine 116:395 (5) (1992).
Tobon et al, Archives of Pathol. & Lab. Medicine 115:172(3) (1991).
Weier et al, J. Hischem. Cytochem 38:421-426 (1990).
Encyclopedia Britannica, 15th edition (1994) vol. 2, p. 277 Boehringer Mannheim Catalogue, p. 158.
Burns et al J. Clin. Pathol. 38:1085-1092 (1985).

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