Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-05-31
1997-08-05
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 74, 435 692, 435183, 4353201, 435358, 536 232, C12N 900, C12N 1512, C12Q 168, G01N 33573
Patent
active
056541465
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for expression vectors for the production of purified ICEY, hybridization probes for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for ICEY or for polynucleotides encoding ICEY, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
REFERENCES:
Ayala et al, "IL-1 .beta.-Converting Enzyme Is Present in Monocytic Cells as an Inactive 45-kDa Precursor, " J Immunol 53:2592-2599 (1994).
Abbas et al, "Effector Mechanisms of Immune Responses, " Cellular and Molecular Immunology, Chapter 12, pp. 240-260, W.B. Saunders Company (1994).
Li et al., "Mice Deficient in IL-1.beta.-Converting Enzyme are Defective in Production of Mature IL-1.beta. and Resistant to Endotoxic Shock, " Cell 80:401-411 (1995).
Howard et al., "IL-1-Converting Enzyme Requires Aspartic Acid Residues for Processing of the IL-.beta. Precursor at Two Distinct Sites and does not Cleave 31-kDa IL-1.alpha., " J. Immunol 147:2964-2969 (1991).
Carruth et al., "Involvement of a Calpain-like Protease in the Processing of the Murine Interleukin 1.alpha.Precursor, " J Biol Chem 266:12162-12167 (1991).
Miura et al., "Induction of Apoptosis in Fibroblasts by IL-1.beta.-Converting Enzyme, a Mammalian Homolog of the C. Elegans Cell Death Gene ced-e, " Cell 75:653-660 (1993).
Walker et al., "Crystal Structure of the Cysterine Protease Interleukin-1.beta.-Converting Engyme: A (p20/p10).sub.2 Homodimer, " Cell 78:343-352 (1994).
Yuan et al., "The C. Elegans Cell Death Gene ced-3 Encodes a Protein Similar to Mammalian Interleukin-1.beta.-Converting Enzyme," Cell 75:641-652 (1993).
Dinarello et al., "The Role of Interleukin-1 in Disease," N Engl J Med 328:106-13 (1993).
Tsuchiya et al., "Establishment and Characterization of a Human Acute Monocytic Leukemia Cell Line (THP-1), " Int J Cancer 26:171-176 (1980).
Auwerx, "The human leukemia cell line, THP-1: A multifacetted model for the study of monocyte-macrophage differentiation," Experientia 47:22-31 (1991).
Cochran et al., "Regulation of interleukin-1.beta. and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1, " Agents and Actions 27:271-273 (1989).
Cerretti et al., "Molecular Cloning of the Interleukin-1beta Converting Enzyme", Science, vol. 226, pp. 97-100. Apr. 3, 1992.
Miller et al., "Purification and Characterization of Active Human Interleukin-1beta-Converting Enzyme from THP.1 Monocytic Cells", The Journal of Biological Chemistry, vol. 268, No. 24, pp. 18062-18069. Aug. 25, 1993.
Miura et al., "Induction of Apoptosis in Fibroblasts by IL-1beta-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3", Cell, vol. 75, pp. 653-660. Nov. 19, 1993.
Munday et al., "Molecular cloning and pro-apoptotic activity of ICEre1II and ICEre1III, . . . " J. Of Biological Chemistry, 270(26):15870-15876 (1995).
Faucheu et al., "A novel protease similar to the interleukin-1-beta converting enzyme induces apoptosis in transfected cells," Embo Journal, 14(9):1914-1922.
Braxton Scott Michael
Delegeane Angelo M.
Diep Dinh
Billings Lucy J.
Elliott George C.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Nelson Amy J.
LandOfFree
Human ice homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human ice homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human ice homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1074053