Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
2000-01-04
Reeves, Julie
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 530300, 530326, 4241461, 4241391, 424 944, 435 696, 435 7021, 435331, 435338, A61K 39395, C12N 520
Patent
active
060111399
ABSTRACT:
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed. Monoclonal antibodies specific for GAD peptides and hybridoma cells producing such are also disclosed.
REFERENCES:
patent: 4487830 (1984-12-01), Coates et al.
patent: 4624926 (1986-11-01), Inouye et al.
patent: 4751181 (1988-06-01), Keene
patent: 5200318 (1993-04-01), Rabin et al.
Baekkeskov et al., "Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis", Diabetes (1989), 38:1133-1141.
Wraith et al., "Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy", Cell (1989), 59:247-255.
Gerling et al., "Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-M Autoantigen and Glucose Sensitivity of Islets Before Development of . . . ", Diabetes (1988), 37:1419-1425.
Dyrberg, "Molecular Mimicry and Diabetes", Current Topics in Microbiology & Immun. (1989), 145:118-125.
Julien et al., "Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA", J. of Neurochemistry (1990), 54:703-705.
Schwimmbeck et al., "Molecular Mimicry and Myasthenia Gravis", J. Clin. Invest. (1989), 84:1174-1180.
Todd et al., "A Molecular Basis for Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus", TIG (1988), 4:129-134.
Chang and Gottlieb, "Characterization of the Proteins Purified with Monoclonal Antibodies to Glutamic Acid Decarboxylase", J. of Neuroscience (1988), 6:2123-2130.
Legay et al., "Evidence for Two Distinct Forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study", J. of Neurochemistry (1987), 48:1022-1026.
Julien et al., "Molecular Cloning, Expression and in situ Hybridization of Rat Brain Glutamic Acid Decarboxylase Messenger RNA", Neuroscience Letters (1987), 73:173-180.
Baekkeskov et al., "Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-Synthesizing Enzyme Glutamic Acid Decarboxylase", Nature (1990), 347:151-156.
Michelesen et al., "Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamic Acid Decarboxylase in Insulin-Dependent Diabetes Mellitus", P.N.A.S. USA (1991), 88:8754-8758.
Solimena et al., "Autoantibodies to GABA-.sup.ergic Neurons and Pancreatic Beta Cells in Stiffman Syndrom", N. Engl. J. Med. (1990) 322:1555-1560.
Kobayashi et al., "Glutamic Acid Decarboxylase cDNA: Nucleotide Sequence Encoding an Enzymatically Active Fusion Protein", J. of Neuroscience (1987), 9:2768-2772.
Atkinson and Maclaren, "What Causes Diabetes?", Sci. Amer. (1990), 62-71.
Baekkeskov et al., "Autoantibodies in Newly Diagnosed Diabetic Children Immunoprecipitate Human Pancreatic Islet Cell Proteins", Nature (1982), 298:167-169.
Baekkeskov et al., "Antibodies to a 64,000 M.tau. Human Inslet Cell Antigen Precede the Clinical Onset of Insulin-Dependent Diabetes", J. Clin. Invest. (1987), 79:926-934.
Christie et al., "Cellular and Subcellular Localization of an M.tau. 64,000 Protein Autoantigen in Insulin-Dependent Diabetes", J. Bio. Chem. (1990), 265:376-381.
Atkinson et al., "64,000 M.tau. Autoantibodies as Predictors of Insulin-Dependent Diabetes", The Lancet (1990), 335:1357-1360.
Ziegler et al., "Predicting Type I Diabetes", Diabetes Care (1990), 13:762-775.
Kaufman et al., "Brain Glutamate Decarboxylase Cloned in .lambda.gt-11: Fusion Protein Produces .tau.-Aminobutyric Acid", Science (1986), 232:1138-1140.
Wyborski et al., "Characterization of a cDNA Coding for Rat Glutamic Acid Decarboxylase", Molecular Brain Research (1990), 8:193-198.
Katarova et al., "Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse", European J. of Neuroscience (1990), 2:190-202.
Persson et al., "Expression of the Neurotransmitter-Synthesizing Enzyme Glutamic Acid Decarboxylase in Male Germ Cells", Molecular and Cellular Biology (1990), 10:4701-4711.
Erlander Mark G.
Kaufman Daniel L.
Tobin Allan J.
Reeves Julie
The Regents of the University of California
Trecartin Richard F.
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