Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-05-07
2000-09-19
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514449, A61K 3153, A61K 31335
Patent
active
061212636
ABSTRACT:
The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologically acceptable salts of said compound; and administering to the mammal from about one half hour to about twenty-four hours after administering the 1,2,4-benzotriazine oxide an effective amount of a chemotherapy agent to which the tumor is susceptible. The invention also provides kits for treatment of such tumors which comprise a chemotherapy agent and a cytotoxicity-enhancing amount of a 1,2,4-benzotriazine oxide as defined in Formula I.
REFERENCES:
patent: 5175287 (1992-12-01), Lee et al.
Holden et al. (Feb. 5, 1992) J. National Cancer Inst. 84: 187-193.
Murray et al. (1983) Br. J. Cancer 47: 195-203.
Zeman et al., (1986) J. Radiation Oncology Biology Physics, vol. 12, No. 7.
The Merck Index, Merck & Co., Inc., Eleventh Edition, (1989).
The Merck Index, 11.sup.th Ed, 1989, p. 1435 (No. 9049) Merck & Co., Inc., Rahway, N.J.
Alexander Michael D.
Goldberg Jerome D.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
Method of tumor treatment does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of tumor treatment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of tumor treatment will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1073404