Method of tumor treatment

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514449, A61K 3153, A61K 31335

Patent

active

061212636

ABSTRACT:
The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologically acceptable salts of said compound; and administering to the mammal from about one half hour to about twenty-four hours after administering the 1,2,4-benzotriazine oxide an effective amount of a chemotherapy agent to which the tumor is susceptible. The invention also provides kits for treatment of such tumors which comprise a chemotherapy agent and a cytotoxicity-enhancing amount of a 1,2,4-benzotriazine oxide as defined in Formula I.

REFERENCES:
patent: 5175287 (1992-12-01), Lee et al.
Holden et al. (Feb. 5, 1992) J. National Cancer Inst. 84: 187-193.
Murray et al. (1983) Br. J. Cancer 47: 195-203.
Zeman et al., (1986) J. Radiation Oncology Biology Physics, vol. 12, No. 7.
The Merck Index, Merck & Co., Inc., Eleventh Edition, (1989).
The Merck Index, 11.sup.th Ed, 1989, p. 1435 (No. 9049) Merck & Co., Inc., Rahway, N.J.

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