Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1998-03-30
2000-09-19
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514138, 558169, 558386, 562 16, 564 15, A61K 31675, C07F 902, C07F 922
Patent
active
061212520
ABSTRACT:
The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
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Tanner et al., "Phosphinate Inhibitors of the D-Glutamic Acid-Adding Enzyme of Peptidoglycan Biosynthesis," J. Org. Chem, 1996, 61(5), 1756-60.
Jackson Paul F.
Ko Yao-Sen
Slusher Barbara S.
Tsukamoto Takashi
Chong Suet M.
Guilford Pharmaceuticals Inc.
Lambkin Deborah C.
Nath Gary M.
Sackey Ebenezer
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