Treatment of balance impairments

Details Treatment of balance impairments Treatment of balance impairments

1995-12-29

2000-09-19

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 436 63, 436 86, 436 87, A61K 3800

Patent

active

061212350

ABSTRACT:
Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons, in an animal by administration of an effective amount of a trkB or trkC agonist, particularly a neurotrophin, more preferably NT-4/5.

REFERENCES:
patent: 5837681 (1998-11-01), Magal
Anniko et al., "Cisplatin: Evaluation of its Ototoxic Potential" Am. J. Otolaryngol. 7:276-293 (1986).
Apfel et al., "Nerve Growth Factor Prevents Toxic Neuropathy in Mice" Annals of Neurology 29(1):87-90 (Jan. 1991).
Ard et al., "Trophic Interactions Between the Cochleovestibular Ganglion of the Chick Embryo and its Synaptic Targets in Culture" Neuroscience 16(1):151-170 (1985).
Au et al., "Aminoglycoside Antibiotics Preferentially Increase Permeability in Phosphoinositide-containing membranes: a Study with Carboxyfluorescein in Liposomes" Biochimica et Biophysica Acta 902:80-86 (1987).
Baird et al., "Cerebellar Target Neurons Provide a Stop Signal for Afferent Neurite Extension in vitro" The Journal of Neuroscience 12(2):619-634 (Feb. 1992).
Barbacid, "The Trk Family of Neurotrophin Receptors: Molecular Characterization and Oncogenic Activation in Human Tumors" Molecular Genetics of Nervous System Tumors pp. 123-136 (1993).
Barde et al., "Purification of a New Neurotrophic Factor From Mammalian Brain" EMBO Journal 1(5):549-553 (1982).
Bareggi et al., "Gentamicin Ototoxicity: Histological and Ultrastructural Alterations After Transtympanic Administration" Pharmacological Research 22(5):635-644 (1990).
Barker et al., "Disruption of NGF Binding to the Low Affinity Neurotrophin Receptor p75.sup.LNTR Reduces NGF Binding to TrkA on PC12 Cells" Neuron 13:203-215 (1994).
Berggren et al., "Intermediate Filament Proteins in the Embryonic Inner Ear of Mice Under Normal Conditions and After Exposure to Ototoxic Drugs" Acta Otolaryngol 109:57-65 (1990).
Berkemeier et al., "Neurotrophin-5: A Novel Neurotrophic Factor That Activates trk and trkB" Neuron 7:857-866 (Nov. 1991).
Boettcher et al., "Concentration of Salicylate in Serum and Perilymph of the Chinchilla" Arch. Otolaryngol Head Neck Surg. 116:681-684 (1990).
Boettcher et al., "Effects of Sodium Salicylate on Evoked-response Measures of Hearing" Hearing Research 42:129-142 (1989).
Boettcher et al., "Salicylate Ototoxicity: Review and Synthesis" Am. J. Otoloaryngol. 12:33-47 (1991).
Carenza et al., "Peripheral Neuropathy and Ototoxicity of Diclorodiamineplatinum: Instrumental Evaluation" Gynecologic Oncology 25:244-249 (1986).
Chao, "Gene Transfer and Molecular Cloning of the Human NGF" Science 232:518-521 (1986).
Chao, "Growth Factor Signaling: Where is the Specificity?" Cell 68:995-997 (Mar. 20, 1992).
Clary et al., "An Alternatively Spliced Form of the Nerve Growth Factor Receptor TrkA Confers an Enhanced Response to Neurotrophin 3" Proc. Natl. Acad. Sci. USA 91:11133-11137 (1994).
Clary et al., "TrkA Cross-linking Mimics Neuronal Responses to Nerve Growth Factor" Molecular Biology of the Cell 5:549-563 (1994).
Cohen et al., "Neurotrophin-4/5 (NT-4/5) Increase Adult Rat Retinal Ganglion Cell Survival and Neurite Outgrowth in vitro" Journal of Neurobiology 25(8):953-959 (1994).
Cordon-Cardo et al., "The trk Tyrosine Protein Kinase Mediates the Mitogenic Properties of Nerve Growth Factor and Neurotrophin-3" Cell 66:173-183 (Jul. 12, 1991).
Corwin et al., "Auditory Hair Cells: Structure, Function, Development, and Regeneration" Annu. Rev. Neuroscience 14:301-333 (1991).
Cotanche et al., "Regeneration of Hair Cells in the Vestibulocochlear System of Birds and Mammals" Current Opinion in Neurobiology 4:509-514 (1994).
Davies et al., "Different Factors From the Central Nervous System and Periphery Regulate the Survival of Sensory Neurones" Nature 319:497-499 (1986).
Davies et al., "Neurotrophin-4/5 Is a Mammalian-specific Survival Factor for Distinct Populations of Sensory Neurons" J. Neuroscience 13(11):4961-4967 (Nov. 1993).
Davies et al., "p75-Deficient Trigeminal Sensory Neurons Have an Altered Response to NGF but Not to Other Neurotrophins" Neuron 11:565-574 (Oct. 1993).
De Moura, "Inner Ear Pathology in Acoustic Neurinoma" Arch Otolaryng. 85:21-29 (125-133) (Feb. 1967).
Dublin, "Anatomic Principles With Some Functional and General Pathologic Applications" Fundamentals of Sensorineurual Auditory Pathology (Chapter 3), Springfield, Illinois:Charles C. Thomas pp. 18-103 (1976).
Duckert et al., "Morphological Correlates of Functional Recovery in the Chicken Inner Ear After Gentamycin Treatment" The Journal of Comparitive Neurology 331:75-96 (1993).
Ernfors et al., "Function of the Neurotrophins in the Auditory and Vestibular Systems: Analysis of BDNF and NT-3 Gene Knockout Mice" ARO Abstracts (Abstract 759) pp. 190 (1995).
Ernfors et al., "Mice Lacking Brain-derived Neurotrophic Factor Develop with Sensory Deficits" Nature 368:147-149 (Mar. 10, 1994).
Ernfors et al., "Molecular Cloning and Neurotrophic Activities of a Protein With Structural Similarities to Nerve Growth Factor: Developmental and Topographical expression in the brain" Proc. Natl. Acad. Sci. USA 87:5454-5458 (Jul. 1990).
Escandon et al., "Regulation of Neurotrophin Receptor Expression During Embryonic and Postnatal Development" The Journal of Neuroscience 14(4):2054-2068 (Apr. 1994).
Falbe-Hansen, "Clinical and Experimental Histological Studies on Effects of Salicylate and Quinine on the Ear" Acta Otolaryng. Supp. 44:1-216 (1941).
Farinas et al., "Severe Sensory and Sympathetic Deficits in Mice Lacking Neurotrophin-3" Nature 369:658-661 (Jun. 23, 1994).
Fischer et al., "Reversal of Spatial Memory Impairments in Aged Rats by Nerve Growth Factor and Neurotrophins 3 and 4/5 but not by Brain-Derived Neurotrophic Factor" Proc. Natl. Acad. Sci. USA 91:8607-8611 (Aug. 1994).
Forge et al., "Ultrastructural Evidence for Hair Cell Regeneration in the Mammalian Inner Ear" Science 259:1616-1619 (Mar. 12, 1993).
Fritzsch, "Mice Homozygous for a Non-functional trk-B Receptor Lack Selectivity in th Innervation of Semicircular Canals" ARO Abstracts (Abstract 760) pp. 190 (1995).
Furley et al., "The Axonal Glycoprotein TAG-1 is an Immunoglobulin Superfamily Member with Neurite Outgrowth-Promoting Activity" Cell 61:157-170 (Apr. 6, 1990).
Gao et al., "Cerebellar Granule Cell Neurogenesis is Regulated by Cell-Cell Interactions in Vitro" Neuron 6:705-715 (May 1991).
Gao et al., "Neurotrophin-3 Reverses Experimental Cisplatin-induced Peripheral Sensory Neuropathy" Annals of Neurology 38(1):30-37 (Jul. 1995).
Gao et al., "Neurotrophin-4/5 (NT-4/5) and Brain-Derived Neurotrophic Factor (BDNF) Act at Later Stages of Cerebellar Granule Cell Differentiation" The Journal of Neuroscience 15(4):2656-2667 (Apr. 1995).
Garner et al., "Isoforms of the Avain TrkC Receptor: A Novel Kinase Insertion Dissociates Transformation and Process Outgrowth From Survival" Neuron 13:457-472 (1994).
Gotz et al., "Neutrophin-6 is a New Member of the Nerve Growth Factor Family" Nature 372:266-269 (1994).
Gotz et al., "Production and Characterization of Recombinant Mouse Neutrophin-3" European Journal of Biochemistry 204:745-749 (1992).
Guild et al., "Correlations of Differences in the Density ofInnervation of the Organ of Corti with Differences in the Acuity of Hearing Including Evidence as to the Location in the Human Cochlea of the Receptors for Certain Tones" Acta Oto-Laryngologica, Holmgren vol. XV:269-308 (1931).
Jones et al., "Molecular Cloning of a Human Gene That is a Member of the Nerve Growth Factor Family" Proc. Natl. Acad. Sci. USA 87:8060-8064 (1990).
Kaplan et al., "The trk Proto-Oncogene Product: A Signal Transducing Receptor for Nerve Growth Factor" Science 252:554-558 (Apr. 16, 1991).
Kaplan et al., "Tyrosine Phosphorylation and Tyrosine Kinase Activity of the trk Proto-oncogene Product Induced by NGF" Nature 350:158-160 (Mar. 14, 1991).
Kelley et al., "The Development Organ of Corti Contains Retinoic Acid and Forms Supernumerary Hair Cells in Response to Exogenous Retinoic Acid in Culture" Development 119:1041-1053 (1993).
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