Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzy

Details Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzy Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzy

1997-11-26

2000-01-04

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514329, 514590, 514604, 546221, 546231, 564 36, 564 92, A01N 4340, A01N 4734, C07D21122, C07C28102

Patent

active

060110473

ABSTRACT:
The present invention provides peptide aldehydes having a 3-amino-2-hydroxyphyenyl-acetamide group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described. Also described are 3-amino-2-hydroxyphenyl-acetamide derivatives having inhibitory activity toward proteases of the trypsin/chymotrypsin class.

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