Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-09-03
2000-01-04
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514255, 544405, 544408, A61K 31495, C07D40112, C07D40312, C07D41312
Patent
active
060110384
ABSTRACT:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## for example: ##STR2##
REFERENCES:
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5405854 (1995-04-01), Ackermann et al.
patent: 5459142 (1995-10-01), Tone et al.
patent: 5510369 (1996-04-01), Lumma et al.
patent: 5744486 (1998-04-01), Sanderson et al.
patent: 5866573 (1999-02-01), Sanderson et al.
Hirsh et al., Chest,vol. 114,pp. 489S-504S, 1998.
Sanderson, P.E., et al., "Preparation of 3-amino-2-pyrazinone-1-acetamide derivatives as thrombin inhibitors," Chem. Abstr., vol. 128, No. 3, p. 532, (1998).
Peter R. Bernstein, et al., "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . " J. Med. Chem., vol. 37, 1994, pp. 3313-3326.
Dorsey Bruce D.
Lyle Terry A.
Sanderson Philip E.
Bernhardt Emily
Merck & Co. , Inc.
Parr Richard S.
Winokur Melvin
LandOfFree
Pyrazinone thrombin inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrazinone thrombin inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazinone thrombin inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1072848