Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-14
2000-01-04
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 6, 4353201, 435325, 4352523, 536 231, 536 2431, 530350, C12P 2106, C12Q 168, C07H 1700, C07K 1400
Patent
active
060108797
ABSTRACT:
The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
REFERENCES:
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Naylor, D.J. et al., "Isolation and characterisation of a cDNA encoding rat mitochondrial GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous appearance in mammalian organs", Febs Letts., 396: 181-188 (1996) (GI 1695878).
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Bandman Olga
Goli Surya K.
Carlson Karen Cochrane
Incyte Pharmaceuticals Inc.
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