Desaturase antigen of mycobacterium tuberculosis

Details Desaturase antigen of mycobacterium tuberculosis Desaturase antigen of mycobacterium tuberculosis

1997-07-25

2000-01-04

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435189, 435325, 435410, 43525411, 4352523, 43525233, 4353201, 536 232, 536 231, 536 237, C12Q 168, C12N 120, C07H 2104

Patent

active

06010855&

ABSTRACT:
The present invention relates to the isolation of a new gene, des, which encodes a M. tuberculosis protein named DES. The des gene appears to be conserved among different Mycobacteria species. The amino acid sequence of the DES protein contains two sets of motifs that are characteristic of the active sites of enzymes from the class II diiron-oxo protein family. Among this family of proteins, DES shares significant homology with soluble stearoyl-ACP desaturases. DES is a highly antigenic protein, which is recognized by human sera from patients infected with M. tuberculosis and M. leprae but not by sera from tuberculous cattle. Thus, the DES protein provides a useful tool for the serodiagnostic analysis of tuberculosis.

REFERENCES:
Lim et al., "Identification of Mycobacterium tuberculosis DNA Sequences Encoding Exported Proteins by Using phoA Gene Fusions", Journal of Bacteriology, vol. 177, No. 1, pp. 59-65, (Jan. 1995).
Philipp et al. "An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, . . . " Proc. Natl. Acad. Sci. U. S. A. 93, 3132-3137, Apr. 1996.
Jackson et al. "Mycobacterium tuberculosis Des protein: an immunodominant . . . " Infection and Immunity 65, 2883-2889, Jul. 1997.

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