Transdermal delivery of highly ionized fat insoluble drugs

Details Transdermal delivery of highly ionized fat insoluble drugs Transdermal delivery of highly ionized fat insoluble drugs

1985-05-03

1987-02-24

Rosenbaum, C. Fred

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

A61K 900

Patent

active

046455027

ABSTRACT:
A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.

REFERENCES:
patent: 3797494 (1973-03-01), Zaffaroni
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4460372 (1984-07-01), Campbell et al.

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