Method and system for obtaining target infusion dosage

Details Method and system for obtaining target infusion dosage Method and system for obtaining target infusion dosage

1995-06-06

1997-08-05

Buiz, Michael Powell

Surgery

Blood drawn and replaced or treated and returned to body

604 49, 604 65, 128DIG3, A61M 3700, A61M 3100

Patent

active

056536810

ABSTRACT:
A method and system are disclosed for more accurate administration of a composition being infused into a body fluid having formed elements. The improved accuracy is due to a correction factor that corrects for the relative impermeability of the formed elements to the infused composition. In one embodiment, the infusion system is a cardioplegia system in which a controller receives information pertaining to the hematocrit and initial blood potassium concentration and adjusts blood flow rate and crystalloid (KCl) solution flow rate so as to obtain the desired resulting potassium concentration in the cardioplegia. The invention further includes an infusion system that comprises a controller which uses an equation that relates the correction factor to an index of formed elements in the body fluid, such as the hematocrit. The equation is determined empirically from a series of experiments in which the resulting concentration of the substance infused into the body fluid is correlated to a formed element index of the body fluid, such as hematocrit.

REFERENCES:
patent: 5230341 (1993-07-01), Polaschegg
patent: 5385540 (1995-01-01), Abbott et al.
patent: 5423749 (1995-06-01), Merte et al.
Houerous, D. et al. (1992) Ann. Thorac. Surg. 54:809-16.
Fried, D.W. & Mohamed, H. (1993) Perfusion 8:401-407.

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