Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1996-01-26
2000-01-04
Eisenschenk, Chris
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5142332, 514 82, 514263, 424422, A61F 228, A61F 200
Patent
active
060107111
ABSTRACT:
A class of active agents, and articles and compositions containing them and methods for treating human patients with them, which inhibit bone resorption of all types. This class of active agents comprises phosphodiester inhibiting compositions which inhibit any of interleukin 1 (IL1), interleukin 6 (IL6) and tumor necrosis factor alpha (TNF), which are cytokines that mediate bone resorption. Exemplary compositions in this class include: pentoxifylline; isobutylmethyl xanthine; ciprofloxacin; rolipram; terferol; and the quinolones generally. Each of these IL1/IL6/TNF inhibitors may be administered alone or in combination by a variety of delivery routes and dosage forms, and they may optionally be administered in conjunction with additional active agents including but not limited to metal chelators.
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O'Keefe Regis James
Rosier Randy Nathan
Eisenschenk Chris
University of Rochester
Zeman Mary K.
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