Method of site-specific alteration of RNA and production of enco

Details Method of site-specific alteration of RNA and production of enco Method of site-specific alteration of RNA and production of enco

1990-02-15

1992-09-22

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435183, 935 8, 935 22, 536 28, 536 29, C12N 1511, C12N 900, C07D47500, C07D47532

Patent

active

051497972

ABSTRACT:
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.

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