Process for the preparation of 3-phosphoniummethyl-3-cephem comp

Details Process for the preparation of 3-phosphoniummethyl-3-cephem comp Process for the preparation of 3-phosphoniummethyl-3-cephem comp

1984-09-28

1987-11-10

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50122, A61K 31545

Patent

active

047058510

ABSTRACT:
The invention relates to a process for the preparation of 3-phosphoniummethyl-3-cephem compounds of the formula: ##STR1## wherein R.sub.3 is aryl, or a salt thereof, which is characterized by reacting one equimolar amount of a 3-hydroxymethyl-3-cephem compound of the formula: ##STR2## or a salt thereof, with two or a little over two equimolar amount of triarylphosphine and one or a little over one equimolar amount of iodine, said prepared compounds being useful as intermediates for manufacturing 3-vinyl-3-cephem compounds possessing potent antimicrobial activities.

REFERENCES:
Barton and Ollis, Comprehensive Organic Chemistry, vol. 2, Pergamon, New York, (1979), pp. 1151, 1162.
Chernywk et al., "Synthesis and Properties of Phosphonium . . . Salts . . . ", Chem. Abst. 83:179223p, (1975).

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