Method of using cold-adapted live influenza virus vaccine as an

Details Method of using cold-adapted live influenza virus vaccine as an Method of using cold-adapted live influenza virus vaccine as an

1990-06-27

1992-09-22

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 39149, A61K 3912

Patent

active

051495317

ABSTRACT:
A method of treating a patient for having influenza includes introducing intranasally into said patient a prophylactically or therapeutically effective dosage of an attenuated reassortant live influenza virus as an antiviral agent and effecting by said introduction immediate interference with the growth of said influenza virus.

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Monto et al., The J. of Infect. Dis., vol. 145, No. 1, Jan. 1982, pp. 57- 4.
Maassab, Adaptation and Growth Characteristics of Influenza Virus at 25.degree. C., Nature, Feb. 11, 1967, pp. 612-614.
Maassab, Biologic and Immunologic Characteristics of Cold-Adapted Influenza Virus, Jour. of Immunology, vol. 102, No. 3, pp. 728-732 (1969).
Murphy et al., Infec. Immun. 29, pp. 348-355 (1980).
Maassab et al., Evaluation of a Cold-Recombinant Influenza Virus Vaccine in Ferrets, Journal of Infectious Diseases, vol. 146, No. 6 (Dec. 1982).
Cox et al., Virology, 167, pp. 554-567 (1988).
Clements et al., Resistance of Adults to Challenge with Influenza a Wild-Type Virus After Receiving Live or Inactivated Virus Vaccine, Journal of Clinical Microbiology, vol. 23, No. 1, pp. 73-76 (1986).
Snyder et al., Journal of Virology, 62, pp. 488-495 (1988).
Whitaker Dowling et al., Dominance of Cold-Adapted Vaccine Strains of Influenza a Viruses etc., Genetics and Pathogenicity of Nagative Strand Viruses, Elsevier pp. 402-407 (1989).

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