Trans-sodium crocetinate, methods of making and methods of use t

Details Trans-sodium crocetinate, methods of making and methods of use t Trans-sodium crocetinate, methods of making and methods of use t

1996-10-03

2000-05-09

Carr, Deborah D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514557, 554156, 554202, 554206, 554223, 554224, A61K 3120

Patent

active

060605111

ABSTRACT:
The use of crocetin has been demonstrated to be effective in elevating oxygen diffusivity, and increasing oxygen consumption by the body tissues of a mammal. Crocetin is difficult to solubilize. Sodium crocetinate, formed by reacting crocetin with sodium hydroxide, appears in several isomeric forms. The trans isomer is effective in improving oxygen diffusivity, while the related cis isomer appears not to be. Isolated TSC can be used in place of crocetin, treat a variety of conditions, including hypertension, cardiovascular disease, hemorrhagic shock, papillomas and related conditions.

REFERENCES:
patent: 4046880 (1977-09-01), Gainer
patent: 4176179 (1979-11-01), Gainer
Streitwieser et al., Introduction to Organic Chemistry, 2nd ed., pp. 504-505, 1981.

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