Rho protein

Details Rho protein Rho protein

1997-04-17

2000-05-09

Lau, Kawai

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 4353201, 536 232, 536 235, C12N 916, C12N 121, C12N 1563, C07H 2104

Patent

active

06060297&

ABSTRACT:
The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.

REFERENCES:
Tavitian, A. "RAS proteins and related proteins." (title translated) C.R.Seances Soc.Biol.Fil. (1995) 189(1):7-12. (Abstract in English only).
Hall, A. et al., "Cellular responses regulated by rho-related small GTP-binding proteins." Philos.Trans.R.Soc.Lond.B. (1993) 340:267-271.
Segade, F. et al., "Isolation of Nine Gene Sequences Induced by Silica in Murine Macrophages" J. Immun. (1995)154:2384-2392.
Hotchin, N.A. et al., "The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases." J.Cell Biol. (1995) 131:1857-1865.
Segade, F. et al. (GI 1279555), GenBank Sequence Database (Accession X80638, X80898), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1996).
Ren, M. et al. "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase." Proc.Natl.Acad.Sci.USA (1996) 93:5151-5155.
Database EMBL/GenBank, Accession No. L25081, Fagan et al., "Sequence of rhoC and rhoA small GTP-binding protein cDNAs from human retina", submitted 1993, available Jan. 9, 1995.
Georgiou, G. "Optimizing the production of recombinant proteins in microorganisms" AIChE Journal (Aug. 1988), vol. 34, No. 8, pp. 1233-1248.
Chardin, P. et al. "Coding sequence of human rho cDNAs clone 6 and clone 9", Nucleic Acids Research (Mar. 25, 1988), vol. 16, No. 6, p. 2717.

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