Device for topical localized administration of zinc to tissue

Details Device for topical localized administration of zinc to tissue Device for topical localized administration of zinc to tissue

1998-09-09

2000-05-09

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424642, 602 48, A61F 1300

Patent

active

060600799

ABSTRACT:
A device is provided for the topical localized administration of zinc to tissue. The device comprises a central layer of absorbent material, with the central layer containing a mixture of particulate superabsorbent and zinc chloride that is sandwiched between a first and second layer of perforated polymeric film that is sealed at the edges. The device is activated by exposure to aqueous media prior to application to tissue. The quantity of zinc chloride contained in the device is varied according to the intended use. High levels of zinc chloride are used to form more concentrated solutions or gels for fixation of necrotic, gangrenous or cancerous tissue to facilitate excision or amputation while lower levels are used for more dilute solutions or gels to promote formation of granulation tissue and healing of lesions in non-necrotic tissue. The device is wrapped on the site to be treated or attached by adhesive means and is kept in place for a period appropriate to the intended use.

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Mohs, F.E., "Chemosurgery in Cancer, Gangrene and Infections", Charles C. Thomas, Springfield, IL, 1956, p. 317.
Bailin, P.L.; "Mohs' Chemosurgery for the Treatment of Cutaneous Gangrene"; CUTIS, vol. 21: 476-478, Apr. 1978.
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