Molecular sensing apparatus

Details Molecular sensing apparatus Molecular sensing apparatus

1998-03-31

2000-05-09

Housel, James C.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

422 50, 422 55, 422 56, 422 58, 422 63, 422 69, 422 76, 422 8102, 422 8103, 422 8105, 422 8107, 422 912, 435 4, 435 5, 435 6, 435 71, 435 72, 435 79, 435 90, 435 911, 435 913, 435 915, 435 9151, 4351731, 436149, 436150, 436806, 436807, 530300, 530350, 530333, 5303881, G01N 1506, G01N 114, G01N 3353, G01N 2518, A61K 3800

Patent

active

060600233

ABSTRACT:
A molecular sensing apparatus comprises a first electrode (10), a second electrode (12), a first molecule (20), a second molecule (22), and a third molecule (34). The first molecule (20) has a first chain of nucleic bases (30) and a first group (24). The first group (24) is bound to the first electrode (10). The second molecule (22) has a second chain of nucleic bases (32) and a second group (26). The second group (26) is bound to the second electrode (12). The third molecule (34) is bound to the first molecule (20) and the second molecule (22). A method which uses the molecular sensing apparatus is disclosed.

REFERENCES:
patent: 5605662 (1997-02-01), Heller et al.
patent: 5620850 (1997-04-01), Bamdad et al.
patent: 5653939 (1997-08-01), Hollis et al.
Williams et al., Studies of Oligoonucleotide interactions by hybridisation to Array: influence of dangling ends on duplex yield, Nucleic Acids Research 8:1365-1367 (1994) Mar. 9, 1994.
Gardner et al., Application of conducting polymer technology in microsystems, Sensors and Actuators 51:57-66 (1995) Feb. 8, 1995.
Boguslavsky et al., Applications of redox polymers in biosensors, Solid State Ionics 60:189-197 (1993) Aug. 1, 1993.
"Effect of Guest/Host Interactions on Photoinduced Electron Transfer Reactions", Claudia Turro, Inorg. Chim. Acta (1996), 252(112), 333-338 CODEN: ICHAA3; ISSN: 0020-1693 Abstract.
"Oxidative DNA Damage through Long-Range Electron Transfer", Daniel B. Hall et al., Nature (London) (1996), 382(6593), 731-735. CODEN: NATUAS; ISSN: 0028-0836 Abstract.
"Site-specific Nucleic Acid Recognition", Cynthia M. Dupureur et al., Compr. Supramol. Chem (1996), vol. 5, 295-315. Editor(s): Suslick, Kenneth S. Publisher: Elsevier, Oxford, UK, CODEN: 63GFA6 Abstract.
Rates of DNA Mediated Electron Transfer between Metallointercalators, M.R. Arkin et al, Science (Washington, D.C.) (1996) 273(5274), 475-480, CODEN; SCIEAS; ISSN; 0036-8075 Abstract.
"Oxidative DNA Damage by a Rhodium Intercalator through Long Range Photoinduced Electron Transfer", Daniel B. Hall, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, Aug. 25-29 (1996), INOR-351 Publisher; American Chemical Society, Washington, D.C. CODEN; 63BFAF Abstract.
"The Development of a Synthetic Nuclease: DNA Hydrolysis by a Rhodium Intercalator Containing a Tethered Peptide", M.P. Fitzsimons, Book of Abstracts, 212th ACS National Meeting, Orlando, FLA, Aug. 25-29 (1996), INOR-330 Publisher; American Chemical Society, Washington, D.C. CODEN; 63BFAF Abstract.
"Rhodium Intercalators with Appended Peptides: Recognition and Reaction", J.K. Barton et al., Book of Abstracts, 212th ACS National Meeting, Orlando, FLA, Aug. 25-29 (1996), INOR-179 Publisher; American Chemical Society, Washington, D.C. CODEN; 63BFAF Abstract.
"Excited State Properties of Rh(phi)2(phen)3+ and Related Complexes: a Strong Photooxidant", Claudia Turro et al., Inorg. Chim. Acta (1996), 243(1-2), 101-108. CODEN; ICHAA3; ISSN: 0020-1693 Abstract.
"OS(phen)2dppz2+ in Photoinduced DNA-Mediated Electron Transfer Reactions", R. Erik Holmlin et al, Am. Chem. Soc. (1996), 118(22), 5236-5244. CODEN; JACSAT; ISSN: 0002-7863 Abstract.
"Electron Transfer between Metal Complexes Bound to DNA: is DNA a Wire?", Eric D.A. Stemp et al., Met. Ions Bio. Syst. (1996), 33 (Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules), 325-365. CODEN: MIBSCD; ISSN: 0161-5149 Abstract.
"Recognition of DNA by Octahedral Coordination Complexes", Timothy W. Johann et al., Philos. Trans. R. Soc. London, Ser. A (1996), 354(1706) 299-324, CODEN: PTRMAD; ISSN: 0962-8428 Abstract.
"Recognition of Nucleic Acids by Transition Metal Complexes", Ayesha Sitlani et al., Handbook Met-Ligand Interact. Biol. Fluids: Bioinorg. Chem. (1995), vol. 1, 466-87. Editor(s): Berthon, Guy. Publisher Dekker, New York, NY CODEN:620XAP Abstract.
"Luminescence Quenching in Supramolecular Systems: A Comparison of DNA-and SDS Michelle-Mediated Photoinduced Electron Transfer between Metal Complexes", M.R. Arkin et al., J. Am. Chem. Soc (1996), 118(9), 2267-74. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"Intractions Between DNA-Iintercalated Metal Complexes: Evidence for Rapid Long-Range Electron Transfer?", Eric J.C. Olson, Book of Abstracts, 210th ACS National Meeting, Chicago, IL, Aug. 20-24 (1995), Issue Pt. 2, PHYS-344 Publisher: American Chemical Society, Washington, D.C. CODEN: 61XGAC Abstract.
"Long Range Electron Transfer between Metallointercalators bound to DNA", Erik D.A. Stemp, Book of Abstracts, 210th ACS National Meeting, Chicago, IL, Aug. 20-24 (1995), Issue Pt. 2 PHYS-253 Publisher: American Chemical Society, Washington, D.C. CODEN 61XGAC Abstract.
"Photoinduced Electron Transfer of Rh(III) Complexes with Donors, Acceptors, and DNA", Claudia Turro, Book of Abstracts, 210th ACS National Meeting, Chicago, IL, Aug. 20-24 (1995), Issue Pt. 1 INOR-168C Publisher: American Chemical Society, Washington, D.C. CODEN 61XGAC Abstract.
"Metallointercalators as Probes of the DNA Way" Michelle R. Arkin et al, Adv. Chem. Ser. (1995) 246(Mechanistic Bioinorgnic Chemistry), 449-69, CODEN; ADCSAJ; ISSN; 0065-2393 Abstract.
"Structural Examination of Enantioselective Intercalation: 1H NMR of Rh(en)2phi3+ Isomers Bound to d(GTGCAC)2", Thomas P. Shields, Biochemistry (1995), 34(46), 15049-56. CODEN: BICHAW; ISSN: 0006-2960 Abstract.
"Sequence-Selective DNA Recognition and Photocleavage: A Comparison of Enantiomers of Rh(en) 2phi3+", Thomas P. Shields, Biochemistry (1995), 34(46), 15037-48, CODEN: BICHAW; ISSN: 0006-2960 Abstract.
"1H NMR Structural Evidence for the Sequence-Specific Design of an Intercalator: [Rh[R,R,)-Me2trien]phi]3+ Bound to d(GAGTGCACTC)2", Brian P. Hudson, J. Am. Chem. Soc. (1995), 117(36), 9379-80. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"Proton Transfer Quenching of the MLCT Excited State of Ru(phen)2dppz2+ in Homogeneous Solution and Bound to DNA", Claudia Turro et al, J. Am. Chem Soc. (1995), 117(35), 9026-32. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"Long-Range Photoinduced Electron Transfer Mediated by the DNA Double Heliz", Michelle Arkin et al., Polym. Mater. Sci. Eng (1994), 71, 598-9. CODEN; PMSEDG; ISSN: 0743-0515 Abstract.
"Sequence-Specific DNA Binding by a Rhodium Complex: Recognition Based on Sequence-Dependent Twistability", Robert H. Terbrueggen et al, Biochemistry (1995), 34(26), 8227-34. CODEN; BICHAW; ISSN: 0006-2960 Abstract.
"Construction of Coordinatively Saturated Rhodium Complexes Containing Appended Peptides", Niranjan Y. Sardesai et al, Bioconjugate Chem. (1995), 6(3), 302-12. CODEN: BCCHES; ISSN: 1043-1802 Abstract.
"Electron Transfer between Metallointercalators Bound to DNA: Spectral Identification of the Transient Intermediate", Eric D.A. Stemp et al, J. Am. Chem. Soc (1995), 117(8), 2375-6. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"Os(phen)2(dppz)2+: A Red-Emitting DNA Probe", Erick R. Holmlin et al, Inorg. Chem(1995), 34(1), 7-8, CODEN; INOCAJ; ISSN; 0020-1669 Abstract.
"Photoinduced Electron Transfer through the Double Helix: Is DNA a Wire?", Jacqueline K. Barton, 37th (40 Years of the DNA Double Helix) 171-9. CODEN; PRAWAC; ISSN; 0557-1588 Abstract.
"DNA Photofootprinting with Rh(phi)2bpy3+", Scott L. Klakamp et al, Methods Mol. Biol. (Totowa, N.J.) (1994), 31 (Protocols for Gene Analysis), 331-7. CODEN; MMBIED; ISSN: 1064-3745 Abstract.
"Fast Photoinduced Electron Transfer through DNA Intercalation", Catherine J. Murphy et al, Proc. Natl. Acad Sci. U.S.A. (1994), 91(12), 5315-19. CODEN: PNASA6; ISSN: 0027-8424 Abstract.
"Use of Selective Deuteration and 1H NMR in Demonstrating Major Groove Binding of .increment. [Ru(phen)2dppz]2+ to d(GTCGAC)2", Cynthia M. Dupureur et al, J. Am. Chem. Soc. (1994), 116(22), 10286-7. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"1H-NMR of Rh(NH3) 4phi3+ Bound to d(TGGCCA)2: Classical Intercalation by a Nonclassical Octahedral Metallointercalator", J. Grant Collins et al, J. Am. Chem. Soc. (1994), 116(22), 9840-6. CODEN: JACSAT; ISSN: 0002-7863 Abstract.
"Sequence-Specific Recognition of DNA by Phenanthrenequinone Diimine Complexes of Rhodium(III): Importance of Steric

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