Radioactive medical devices

Details Radioactive medical devices Radioactive medical devices

1999-03-26

2000-05-09

Hindenburg, Max

Surgery

Radioactive substance applied to body for therapy

Radioactive substance placed within body

A61N 500

Patent

active

060597143

ABSTRACT:
An implantable medical device according to the present invention comprises a body, such as a stent or a wire, having a radioisotope or non-radioactive precursor isotope associated with the body. The isotope preferably is disposed on the body using an efficient deposition method, such as an effusion cell. The method reduces the waste of costly isotopes and reduces the buildup of hazardous material in the apparatus. A metal layer may be deposited simultaneously with or subsequent to deposition of the isotope to encapsulate the radioactive isotope.

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patent: 5871437 (1999-02-01), Alt
Fishcell et al., "Low-Dose .beta.-Particle Emission From `Stent` Wire Results in Completw, Localized Inhibition of Smooth Muscle Cell Proliferation," Circulation, 90:2956-2963 (1994).
Laird, J. R. et al., "Inhibition of Neointimal Proliferation with Low-Dose Irradiation From a .beta.-Particle-Emitting Stent," Circulation, 93:529-536 (1996).
Teirstein, P. S. et al., "Catheter-Based Radiotherapy To Inhibit Restenosis After Coronary Stenting", New England Journal of Medicine, 336:1697-1703 (1997).
Wiedermann, J. G. et al., "Intracoronary Irradiation Markedly Recduces Restenosis After Balloon Angioplasty in a Porcine Model," J. Am. Coll. Cardiol., 23:1491-1498 (1994).

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