Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos

Details Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos

1982-05-10

1988-05-24

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544134, 544357, 544367, 546187, 546209, 546256, 546277, 548128, 548129, 548130, 548135, A61K 3141, C07D41712

Patent

active

047466723

ABSTRACT:
Sulphur derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion of the formula I: ##STR1## in which R.sup.1 and R.sup.2 independently are hydrogen or 1-10C alkyl, 3-8C cycloalkyl or 4-14C cycloalkylalkyl, each alkyl, cycloalkyl or cycloalkylalkyl optionally carrying one or more F, Cl or Br atoms, provided that one of R.sup.1 and R.sup.2 is halogen substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene or a 1-8C alkylene chain into which is optionally inserted one or two groups; p is 1 or 2; R.sup.3 is a variety of radicals described in the specification; and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes for the derivatives, intermediates and pharmaceutical compositions are also part of the invention.

REFERENCES:
patent: 4165377 (1979-08-01), Jones et al.
patent: 4165378 (1979-08-01), Gilman et al.
patent: 4234735 (1980-11-01), Jones et al.
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4242351 (1980-12-01), Yellin et al.
patent: 4262126 (1981-04-01), Gilman et al.
patent: 4309435 (1982-01-01), Yellin et al.
patent: 4315009 (1982-02-01), Jones et al.
patent: 4332949 (1982-06-01), Yellin et al.
patent: 4338447 (1982-07-01), Yellin et al.
patent: 4338448 (1982-07-01), Yellin et al.
patent: 4342765 (1982-08-01), Jones et al.
patent: 4347370 (1982-08-01), Gilman et al.
patent: 4362728 (1982-12-01), Yellin et al.
patent: 4374836 (1983-02-01), Yellin et al.

Affiliated with

Also associated with

Rating

Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxides of 1,2,5-thiadiazoles, their use in pharmaceutical compos will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1058669