Process for preparing fluorocarbon fluoroalkanesulfonates

Details Process for preparing fluorocarbon fluoroalkanesulfonates Process for preparing fluorocarbon fluoroalkanesulfonates

1994-11-16

1996-08-27

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

558 52, 558 51, 558 48, 558 47, 558 46, C07C30965, C07C30971, C07C30968, C07C30969

Patent

active

055502733

ABSTRACT:
A process for preparing fluorocarbon fluoroalkanesulfonates comprises (a) forming a mixture comprising at least one fluoroalkanesulfonyl halide, e.g., perfluoromethanesulfonyl fluoride, at least one fluorocarbon-substituted carbinol, e.g., 1,1-dihydroperfluorobutoxyethoxyethanol, and at least one base, e.g., triethyl amine; and (b) allowing the mixture to react in the absence of solvent at a temperature below ambient. The process is volume-efficient and provides high yields of fluorocarbon fluoroalkanesulfonates useful as intermediates in, e.g., drug synthesis.

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