Substituted stryl heterocyclic amido prostaglandin analogs

Details Substituted stryl heterocyclic amido prostaglandin analogs Substituted stryl heterocyclic amido prostaglandin analogs

1990-11-29

1996-08-27

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483114, 548200, C07D49308

Patent

active

055502482

ABSTRACT:
Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula ##STR1## wherein: C.sub.m H.sub.p is an alkylene chain wherein m is 0, 1, 2, or 3 and p=(2.times.m)-1, except that when m is 0, p is also 0;
n is 0, 1, 2 or 3;
R is CO.sub.2 R', CH.sub.2 OH, CONHSO.sub.2 R.sup.3, CONHR.sup.4, or --CH.sub.2 --5--tetrazolyl;
R' is hydrogen, alkyl, or alkali metal;
X is O or NH;
Y is --O--, a single bond or vinylene, except that Y cannot be --O-- when n is 0;
and the remaining symbols are as defined in the specification.

REFERENCES:
patent: 5043451 (1991-08-01), Ohtani
patent: 5100889 (1992-03-01), Misra et al.
As Belo Bioorg Chem, 04.03.81-SU278256 (23 Nov. 1987)CO7c-177 CO7d-261/06.
Chem Abs. SA Selects: Prostaglandins Issue 12, 1988 108:198903m. Kuz'mitskii, B. B. et al.
CA Selects: Prostaglandins, Issue 12, 1988, 108:204363d, Lakhvich, F. A. et al.

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