Process for preparing monoesters predominantly in the 6 position

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536116, 536119, 536124, 514 53, C07H 100, C07H 1304, A61K 31715, C13K 700

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active

055502253

ABSTRACT:
A process for preparing monoesters predominantly in the 6' position of D-maltose involves, in a first step forming in an organic solvent a mixed anhydride of formula (I): ##STR1## wherein R represents a linear or branched alkyl or alkenyl radical having 7-21 carbon atoms or R represents a defined mixture of the alkyl or alkenyl radicals, and R' represents a linear or branched alkyl having 2-10 carbon atoms, by reacting in the presence of a base, an R--COOH acid wherein R has the meaning given above with a ClCOOR' alkyl chloroformate wherein R' has the meaning given above, and in a second step reacting the mixed anhydride of formula (I) in solution in an organic solvent with D-maltose. The monoesters are employed in cosmetic, buccal-dental, pharmaceutical or food compositions.

REFERENCES:
patent: H937 (1991-07-01), Sloan
patent: 4058537 (1977-11-01), Mueller
patent: 4499020 (1985-02-01), Lalezari
Nishikawa et al, "Chemical and Biochemical Studies on Carbohydrate Esters, IV. Antitumor Effect of Selectively Fatty Acylated Products of Maltose", Chemical and Pharmaceutical Bulletin, vol. 29, No. 2, 1981, pp. 505-513.

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