Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-14
1996-08-27
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514357, 546323, 546337, 564166, A61K 3144, C07D21330
Patent
active
055501370
ABSTRACT:
##STR1## Compounds of formula (1) are described wherein Y represents a halogen atom or a group --OR.sup.1 where R.sup.1 represents an optionally substituted alkyl group; R.sup.2 represents an optionally substituted cycloalkyl, cycloalkenyl or polycycloalkyl group; R.sup.3 represents a hydrogen atom or an alkyl, aryl or aralkyl group; R.sup.4 represents an aryl or heteroaryl group; X represents --O--, --S--, --CH.sub.2 -- or --N(R.sup.5)--, where R.sup.5 is a hydrogen atom or an alkyl group; n is zero or an integer or value 1, 2 or 3; and the salts, solvates and hydrates thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.
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Beeley Nigel R. A.
Millican Thomas A.
Celltech Therapeutics Limited
Fan Jane
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