Substituted phenoxydialkylacetic acids and esters

Details Substituted phenoxydialkylacetic acids and esters Substituted phenoxydialkylacetic acids and esters

1975-01-20

1976-11-30

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260520C, 424308, C07C 6976

Patent

active

039949559

ABSTRACT:
The present invention encompasses compounds of the formula ##SPC1##
Wherein R.sub.1 is lower alkyl containing 1-7 carbon atoms, phenyl, halo(substituted)phenyl, phenyl, or lower alkoxy (substituted)phenyl containing 1-7 carbon atoms; R.sub.2 and R.sub.3 are lower alkyl containing 1-7 carbon atoms; and R.sub.4 is hydrogen or lower alkyl containing 1-7 carbon atoms. The compounds of the present invention are prepared by the condensation of alkyl(4-formylphenoxy)-2,2-dialkyl acetate with an appropriate alkyl or aryl methyl/ketone in base. These compounds have antibiotic activity and in particular they are antifungal agents effective against Trichophyton mentagrophytes. Halophenyl members of the present invention are also effective hypolipemic agents.

REFERENCES:
patent: 3458565 (1969-07-01), Bicking et al.

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