Process for the manufacture of peptides containing cystine

Details Process for the manufacture of peptides containing cystine Process for the manufacture of peptides containing cystine

1974-05-20

1976-11-30

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601127, C07C10352, A61K 3726, C07G 700

Patent

active

039948714

ABSTRACT:
Process for the manufacture of peptides which contain more than one disulphide bond characterized in that in one or two aminoacid sequences containing cysteine, in which disulphide bonds are to be produced, two cysteine radicals which are to be linked are protected by a mercapto-protective group R.sub.1 of the aralkyl type, two further cysteine radicals are protected by an acylaminomethyl group R.sub.2, the protective groups R.sub.1 are removed by treatment with iodine in the presence of a polyhalogenated lower aliphatic hydroxy compound or oxo compound, or a corresponding lower alkanoic acid lower alkyl ester, at the same time forming the disulphide bond between these cysteine radicals, which are protected by R.sub.1, and at any desired point after removal of the polyhalogenated compound the second disulphide bridge is formed in the usual manner.

REFERENCES:
hermann et al.: Chem. Abstr. 78: 136,656m, (1973).
Kamber: Chem. Abstr. 78: 124,894z, (1973).
Moroder et al.: Chem. Abstr. 78: 160,089z, (1973).

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