Preparation process of .alpha.-l-aspartyl-l-phenyl-alanine methy

Details Preparation process of .alpha.-l-aspartyl-l-phenyl-alanine methy Preparation process of .alpha.-l-aspartyl-l-phenyl-alanine methy

1989-05-25

1990-04-17

Gray, Bruce D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10102

Patent

active

049182161

ABSTRACT:
.alpha.-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying .alpha.-L-aspartyl-L-phenylalanine or .alpha.-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-.alpha.-L-aspartyl-L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting .alpha.-L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide.

REFERENCES:
patent: 3833553 (1974-09-01), Ariyoshi et al.
patent: 3879372 (1975-04-01), Boesten
patent: 3933781 (1976-01-01), Bachman et al.
patent: 3962207 (1976-06-01), Uchiyama et al.
patent: 4021418 (1977-05-01), Takemoto et al.
patent: 4071511 (1978-01-01), Takemoto et al.
patent: 4088649 (1978-05-01), Smith
patent: 4153737 (1979-05-01), Berg et al.
patent: 4173562 (1979-11-01), Bachman et al.
patent: 4333872 (1982-06-01), Sampathkumar et al.
patent: 4634790 (1987-01-01), Shinohara et al.
patent: 4740616 (1988-04-01), Takemoto et al.
patent: 4801732 (1989-01-01), Mita et al.
Chemical Abstracts, 80, 452, 96371X (1974).
Chemical Abstracts, 98019w, vol. 78, No. 15.
Chemical Abstracts, 105:153551s (1986).
World Patent Index (English Language Abstract of Japanese 60-174799).

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