Process of producing 8A- and 9A-azalide antibiotics

Details Process of producing 8A- and 9A-azalide antibiotics Process of producing 8A- and 9A-azalide antibiotics

1993-04-14

1994-07-26

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

540463, 540467, C07D27301, C07H 1708

Patent

active

053328078

ABSTRACT:
A process of producing 8a- and 9a- azalide compounds is disclosed, comprised of reacting an 8a- aza or 9a- aza azalide eastern fragment or a derivative thereof with a compound of the formula:

REFERENCES:
patent: 3869444 (1975-03-01), Freiberg
patent: 3979511 (1976-09-01), Hung et al.
patent: 4152424 (1979-05-01), Kierstead et al.
patent: 4328334 (1982-05-01), Kobrehel et al.
patent: 4349545 (1982-07-01), Gouin d/Ambrieres et al.
patent: 4464527 (1984-08-01), Bright et al.
patent: 4465674 (1985-08-01), Bright et al.
patent: 4492688 (1985-01-01), Bright et al.
patent: 4512982 (1985-04-01), Hauske et al.
patent: 4517359 (1985-05-01), Kobrehel et al.
patent: 4518590 (1985-05-01), Hauske et al.
patent: 4526889 (1985-07-01), Bright
patent: 4680386 (1987-07-01), Morimoto et al.
patent: 4886792 (1989-12-01), Djokic
patent: 4921839 (1990-05-01), Brain et al.
patent: 4957905 (1990-09-01), Hunt et al.
patent: 4990602 (1991-02-01), Morimoto
Djokic, et al., Erythromycin Series 12: Antibacterial in Vitro Evaluation of 10-Dehydro-11-deoxo-11-azaerythromycin A, Journal of Antibiotics, vol. 40, No. 7, (Jul. 1987).
Djokic, et al., Erythromycin Series Part II: Ring Expansion of Erythromycin A Oxime by the Beckman Rearrangement, J. Chem. Soc., Perkins Trans. 1, pp. 1881-1890 (1986).
Djokic, et al., Erythromycin Series Part 13: Synthesis and Structure Elucidation of 10-Dihydro-1-Deoxo-11-methyl-11-aza erythromycin A, J. Chem. Research (S), pp. 152-153 (1988).
Bright, et al., Sythesis, In Vitro and In Vivo Activity of Novel 9-Deoxo-9-a-Aza-9a-Homoerythromycin A Derivatives, The Journal of Antibiotics, vol. 61, No. 8, pp. 1029-1047 (1988).
Massey, et al., Erythromycylamine, Tetrahedron Letters, No. 2, pp. 157-160 (1970).
Gasc et al., New Ether Oxime Derivatives of Erythromycin A, The Journal of Antibiotics, vol. 44, No. 3, pp. 313-329 (1990).
Thornsberry et al., The Macrolide Revival: 35 Years After Erythromycin, Antimicrobic Newsletter, vol. 4, No. 4, pp. 25-36 (1987).
Egan, et al., Configuration of 9-Imino Derivatives of Erythromycin, J. Org. Chem., vol. 39, pp. 2492-2494, (1974).
Jones, Brian A., J. Org. Chem., (1992) 57(16) 4361-4367.

Affiliated with

Also associated with

Rating

Process of producing 8A- and 9A-azalide antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of producing 8A- and 9A-azalide antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of producing 8A- and 9A-azalide antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1053863