Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-11-23
1994-07-26
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 95, 514102, 514108, A61K 3166
Patent
active
053327284
ABSTRACT:
A method is provided for treating a fungal infection which includes the step of administering a therapeutically effective amount of a phosphorus-containing squalene synthetase inhibitor.
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Baxter, A. et al, "Squalestin 1, a Potent Inhibitor of Squalene Synthase, Which Lowers Serum Cholesterol in Vivo" Journal of Biological Chemistry, vol. 267, No. 17, pp. 11705-11708, 1992.
Dawson, M. J., "The Squalestatins, Novel Inhibitors of Squalene Synthase Produced by a Species of Phoma" The Journal of Antibiotics, vol. 45 No. 5, pp. 639-658, May 1992.
Bristol--Myers Squibb Company
Killos Paul J.
Rodney Burton
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