Phenyl glycines for use in reducing neurotoxic injury

Details Phenyl glycines for use in reducing neurotoxic injury Phenyl glycines for use in reducing neurotoxic injury

1987-10-21

1990-04-17

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558178, 558190, 562 11, 562 14, 564 14, C07F 938, C07F 940, A01K 3166

Patent

active

049180649

ABSTRACT:
A class of phenyl glycine compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phenyl glycine compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.

REFERENCES:
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4761405 (1988-08-01), Rzeszotarski et al.
S. M. Rothman and J. W. Olney, Annals of Neurology, vol. 19, No. 2 (1986).
M. N. Perkins et al., Neuroscience Lett., 23, 333 (1981).
J. Davies et al., Neuroscience Lett., 21, 77 (1981).
K. Matoba et al., Chem. Pharm. Bull., 32, (10) 3918-3925 (1984).
J. W. Olney et al., Neuroscience Letters, 68, 29-34 (1986).

Affiliated with

Also associated with

Rating

Phenyl glycines for use in reducing neurotoxic injury does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenyl glycines for use in reducing neurotoxic injury, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenyl glycines for use in reducing neurotoxic injury will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1052841