Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1991-09-20
1993-09-21
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530402, 530395, 424 851, 930144, 435 695, 435 697, C07K 1300
Patent
active
052470709
ABSTRACT:
A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of cell-adherent peptide of laminin and from 5 to 30 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.
REFERENCES:
patent: 4677063 (1987-06-01), Mark et al.
patent: 5095096 (1942-03-01), Miki et al.
Biochemistry, 3rd ed, 1988, Stryer, pp. 277-278.
Biochem, vol. 27(24) 1988, pp. 8780-8787, (abstract only).
Cell, vol. 59(5) 1989, pp. 905-913 (abstract only).
Nippon Kyobu Shikkan Gakkai Zasshi, vol. 30(3), 1992, pp. 402-406 (abstract only).
Aoyama Yoshiyuki
Kato Masanari
Miyata Keizo
Shikama Hiroshi
Yamada Nobutoshi
Draper Garnette D.
Ishihara Sangyo Kaisha Ltd.
LandOfFree
N-terminal muteins of tumor necrosis factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-terminal muteins of tumor necrosis factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-terminal muteins of tumor necrosis factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1051294