19-nor-vitamin D compounds for use in treating hyperparathyroidi

Details 19-nor-vitamin D compounds for use in treating hyperparathyroidi 19-nor-vitamin D compounds for use in treating hyperparathyroidi

1992-10-13

1993-09-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514 63, A61K 3159, A61K 31695

Patent

active

052469255

ABSTRACT:
This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.

REFERENCES:
patent: 4769181 (1988-09-01), DeLuca et al.
Chemical Abstracts (110:19004r) 1989.

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