Solid phase and combinatorial synthesis of compounds on a solid

Details Solid phase and combinatorial synthesis of compounds on a solid Solid phase and combinatorial synthesis of compounds on a solid

1993-12-02

1996-08-13

Bond, Robert T.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436501, 436531, 435 71, 427 21, 427 213, 427 211, 427 223, G01N 33543

Patent

active

055455689

ABSTRACT:
Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, .beta.-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

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