Production of bis-(morpholino-N-alkyl) ethers

Details Production of bis-(morpholino-N-alkyl) ethers Production of bis-(morpholino-N-alkyl) ethers

1976-04-23

1978-06-13

Tovar, Jose

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26528

Patent

active

040950220

ABSTRACT:
An improved process is disclosed for selectively producing a bis-(morpholino-N-alkyl) ether directly from the corresponding N-(hydroxyalkyl)morpholine compound. The improved process includes contacting the N-(hydroxyalkyl)morpholine compound with a catalytically effective amount of a silica-alumina or certain phosphorus containing substances at a temperature of about 200.degree. C to 300.degree. C under a pressure sufficient to maintain the mixture substantially in liquid phase and recovering from the resultant reaction mixture the bis-(morpholino-N-alkyl) ether.
According to the preferred embodiment, N-(2-hydroxyethyl)morpholine is heated in the presence of a catalytic amount of a silica-alumina catalyst having an alumina content of from about 5 to about 50 wt. % at temperatures of from about 240.degree. C to about 290.degree. C in liquid phase to selectively produce the corresponding N,N',2,2'-dimorpholinodiethyl ether (DMDEE).

REFERENCES:
patent: 3112317 (1963-11-01), Marschall et al.
patent: 4026935 (1977-05-01), Brennan et al.

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