Compounds of 1,2,5,6-tetrahydropyridine which are useful as chol

Details Compounds of 1,2,5,6-tetrahydropyridine which are useful as chol Compounds of 1,2,5,6-tetrahydropyridine which are useful as chol

1989-09-15

1993-06-15

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546335, 546338, A61K 3144, C07D21170

Patent

active

052198731

ABSTRACT:
Compounds useful in the treatment of Alzheimer's disease, senile dimentia and memory disorders of the formula ##STR1## in which R represents hydrogen, hydroxyl, a linear, branched or cyclic, saturated or unsaturated, alkyl, containing up to 8 carbon atoms, possibly substituted by free or esterified carboxy or R represents aralkyl containing up to 10 carbon atoms or --COOZ in which Z represents a linear, branched or cyclic saturated or unsaturated, alkyl containing up to 8 carbon atoms and R.sub.2 represents hydrogen or a linear or branched, saturated or unsaturated alkyl containing up to 8 carbon atoms, COalk.sub.1 radical or (CH.sub.2).sub.2 N(alk.sub.2).sub.2, alk.sub.1 and alk.sub.2 representing an alkyl containing up to 8 carbon atoms, as well as their addition salts with acids provided that if R represents an alkyl R.sub.2 does not represent hydrogen; also therapeutic compositions containing at least one said compound and method of treating patients with said compounds.

REFERENCES:
patent: 3004979 (1961-10-01), Druey et al.
patent: 4710508 (1987-12-01), Bergmeir
patent: 4786648 (1988-11-01), Bergmeier et al.

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