Platelet aggregation inhibitory agents

Details Platelet aggregation inhibitory agents Platelet aggregation inhibitory agents

1992-08-10

1993-06-15

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546189, C07D21132, A61K 31445

Patent

active

052198677

ABSTRACT:
The present invention relates to substantially pure stereoisomers of a compound of the formula: ##STR1## wherein n.sub.1 and n.sub.2 are the same or different and are 1 or 2; X is alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10) or aralkyl (C.sub.7 -C.sub.12); and wherein R, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are chosen from H, alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10), aralkyl (C.sub.7 -C.sub.12), or a heterocyclic group, and addition salts thereof with pharmaceutically acceptable acids. The invention also relates to a method for the inhibition of blood platelet aggregation in a blood supply comprising administering to said blood supply a blood platelet aggregation inhibiting amount of the compounds of the present invention.

REFERENCES:
patent: 4634709 (1987-01-01), Lasslo et al.
patent: 4657917 (1987-04-01), Lasslo et al.
Gollamudi, et al., Chirality, 1991, 3, 480-483.

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