Therapeutic nucleosides

Details Therapeutic nucleosides Therapeutic nucleosides

1989-10-06

1991-12-10

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40504

Patent

active

050719831

ABSTRACT:
This invention relates to certain derivatives of 2', 3'-dideoxycytidine and their use in medical therapy particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the manufacture of the compounds according to the invention.

REFERENCES:
Chong-Ho Kim, et al., J. Med Chem., 1987, 30, pp. 862-866, Potential Anti-AID Drugs. 2',3'-Dideoxycytidine Analogues.
Mitsuya, et al., Proc. Natl. Acad. Sci. U.S.A., vol. 82, pp. 7096-7100, Oct. 1985, Medical Sciences, 3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
Prisbe, et al., Synthetic Communications, 15(5), pp. 401-409, 1985, A Novel and Efficient Preparation of 2',3'-Dideoxynucleosides.sup.1.

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