Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1990-08-20
1993-06-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424479, 424480, 424493, 424494, A61K 954, A61K 962
Patent
active
052195759
ABSTRACT:
The present invention relates to compositions having a controlled zero-order delivery rate of the active component. The composition comprises a core or a protective layer coated with a continuous matrix of constant composition containing such a mixture of active substance(s) and excipient(s) that the concentration of the active substance(s) decreases from the core or the protective layer towards the outside, and the concentration of the excipient(s) increases in the same direction, whereas the sum of two substantially remains constant over the whole distance.
REFERENCES:
patent: 4289795 (1981-09-01), Bogentoft et al.
patent: 4341759 (1982-07-01), Bogentoft et al.
patent: 4457907 (1984-07-01), Porter
patent: 4624848 (1986-11-01), Lee
patent: 4749576 (1988-06-01), Lee
Fokkens Jasper G.
Van Bommel Elvira M. G.
Duphar International Research B.V.
Page Thurman K.
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