N-(2-Aminocyclopentyl)acylanilides and treating depression

Details N-(2-Aminocyclopentyl)acylanilides and treating depression N-(2-Aminocyclopentyl)acylanilides and treating depression

1978-04-10

1979-05-22

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260551S, 260557R, 260562R, 424300, 560137, A61K 31165, C07C10320, C07C10322

Patent

active

041560159

ABSTRACT:
N-(2-Aminocyclopentyl)N-alkanoylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System anti-depresssant properties. Many of them are new.
These compounds are promising anti-depressant drugs which are characterized by a better therapeutic ratio than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 3852058 (1974-12-01), Hoffman

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