Sulphur- and oxygen-containing diaryl compounds

Details Sulphur- and oxygen-containing diaryl compounds Sulphur- and oxygen-containing diaryl compounds

1977-04-05

1979-05-22

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

562472, 562427, 544168, 568637, 544158, 544174, 544174, 424244, 544391, 42424857, 4242485, 544159, 424250, 424267, 544162, 424273R, 424274, 544394, 424303, 424308, 544398, 424317, 424326, 260239B, 424330, 424335, 2603265S, 424340, 548353, 26032684, 260456P, 2605012, 260564R, 260558S, 260559D, 2605705S, 2605707, 260607AR, 260609R, 2603265SF, 2603265E, 2603265L, 546232, 546226, 546234, 560 9, 560 11, 560 17, 560 62, 560 63, 562429, 562431, A61K 31235

Patent

active

041560116

ABSTRACT:
The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2,
Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.3 lower alkyl group, or together form, with the nitrogen atom to which they are linked, a N-heterocyclic group of 5 to 7 ring atoms which can be substituted and can comprise a second hetero-atom, and their addition salts with bases when R is COOH, and their addition salts with acids when R is a basic radical, are useful pharmacological agents in the treatment of circulatory complaints such as cardio-vascular illnesses.

REFERENCES:
patent: 3721703 (1973-03-01), Nahm et al.
patent: 3954442 (1976-05-01), Becker et al.
Rousselet, Chem. Abst. 77:96726e (1972).
Rassous, Chem. Abst. 77:96889k (1972).
Debray, Chem. Abst. 77:96890d (1972).

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