Novel renin inhibiting peptides

Details Novel renin inhibiting peptides Novel renin inhibiting peptides

1990-11-28

1991-12-10

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, C07K 508, A61K 3702

Patent

active

050718371

ABSTRACT:
The invention concerns certain orally active novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and glaucoma. It is also useful for treating diseases caused by retroviruses including HTLV-I, -II, and -III. Process for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

REFERENCES:
patent: 4479941 (1984-10-01), Veber et al.
patent: 4855303 (1989-08-01), Hoover et al.
patent: 4857507 (1989-08-01), Rosenberg et al.
patent: 4882420 (1989-11-01), Thaisrivongs
patent: 4985407 (1991-01-01), Foxton et al.
Plattner et al., J. Med. Chem. 1988, 31(12):2277-2288.
Michael H. Gelb et al., "Fluoro Ketone Inhibitors of Hydrolytic Enzymes", Biochemistry, v. 24, No. 8, Apr. 9, 1985, pp. 1813 through 1817-M12.
U.S. Ser. No. 07/384,236 filed Jul. 24, 1989, which is a CIP of 07/206,023 filed Jun. 17, 1988, now abandoned, which is a CIP of 07/113,772 filed Oct. 26, 1987, now abandoned.

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